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. 2009 May 21;113(21):5064-73.
doi: 10.1182/blood-2008-10-184168. Epub 2009 Mar 11.

Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases

Porcia T Bradford  1 , Susan S Devesa, William F Anderson, Jorge R Toro
Affiliations

Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases

Porcia T Bradford et al. Blood. .

Abstract

There have been no prior large population-based studies focusing on cutaneous lymphomas (CL) in the United States. Using the Surveillance, Epidemiology and End Results (SEER) program data, we analyzed age-adjusted CL incidence rates (IRs) and survival rates by sex and race/ethnicity. There were 3884 CLs diagnosed during 2001-2005. Cutaneous T-cell lymphomas (CTCLs) accounted for 71% (age-adjusted incidence rate [IR] = 7.7/1 000 000 person-years), whereas cutaneous B-cell lymphomas(CBCLs) accounted for 29% (IR = 3.1/1 000 000 person-years). Males had a statistically significant higher IR of CL than females (14.0 vs 8.2/1 000 000 person-years, respectively; male-female IR ratio [M/F IRR] = 1.72; P < .001). CL IRs were highest among blacks and non-Hispanic whites (both 11.5/1 000 000 person-years), followed by Hispanic whites (7.9) and Asian/Pacific Islanders (7.1). The CTCL IR was highest among blacks (10.0/1 000 000 person-years), whereas the CBCL IR was highest among non-Hispanic whites (3.5). Over the past 25 years, the CL IR increased from 5.0/1 000 000 person-years during 1980-1982 to 14.3 during 2001-2003. During 2004-2005, the CL IR was 12.7. This recent apparent change could be incomplete case ascertainment or potential leveling off of IRs. CLs rates vary markedly by race and sex, supporting the notion that they represent distinct disease entities.

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Figures

Figure 1
Figure 1
Age-specific cutaneous T-cell lymphoma incidence rates and age distributions at diagnosis from 2001-2005 in the 16 SEER registries by sex. (A-D) Rates per 1 million person-years are shown for (A) all cutaneous T-cell lymphomas (CTCL) combined, (B) mycosis fungoides (MF), (C) primary cutaneous peripheral T-cell lymphoma (pcPTL), and (D) cutaneous CD30+ lymphoproliferative disorders (CD30+ LPD). (E-H) Density plots are shown for (E) all CTCL combined, (F) MF, (G) pcPTL, and (H) CD30+ LPD. Area under the curve includes 100% of cases. The vertical axis for each density plot represents smoothed estimates of the density of patients (density × 100 = %).
Figure 2
Figure 2
Age-specific cutaneous B-cell lymphoma incidence rates and age distributions at diagnosis from 2001-2005 in the 16 SEER registries by sex. (A-D) Rates per 1 million person-years are shown for (A) all cutaneous B-cell lymphomas (CBCL) combined, (B) primary cutaneous marginal zone lymphoma (pcMZL), (C) primary cutaneous follicle center lymphoma (pcFCL), and (D) primary cutaneous diffuse large B-cell lymphoma (pcDLBCL). (E-H) Density plots are shown for (E) all CBCL combined, (F) pcMZL, (G) pcFCL, and (H) pcDLBCL. Area under the curve includes 100% of cases. The vertical axis for each density plot represents smoothed estimates of the density of patients (density × 100 = %).
Figure 3
Figure 3
Cutaneous lymphoma temporal trends during 1980-1982 through 2004-2005. Data are shown by year of diagnosis in the 9 SEER program registries for all CL, CTCL, MF, pcPTL, and CD30+ LPD, and CBCL.
Figure 4
Figure 4
Age-adjusted cutaneous lymphoma incidence rates during 1992-1996 through 2001-2005 in the 12 SEER registries by year of diagnosis and race. (A) All cutaneous lymphomas; (B) all cutaneous T-cell lymphomas (CTCL); (C) mycosis fungoides (MF); (D) primary cutaneous peripheral T-cell lymphomas (pcPTL); and (E) cutaneous B-cell lymphomas (CBCL).
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