Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Aug;38(4):257-62.
doi: 10.1111/j.1600-0684.2009.00350.x. Epub 2009 Mar 5.

Endometrial and cervical polyps in 22 baboons (Papio sp.), 5 cynomolgus macaques (Macaca fascicularis) and one marmoset (Callithrix jacchus)

Melissa W Bennett  1 , Edward J Dick Jr, Natalia E Schlabritz-Loutsevitch, Juan C Lopez-Alvarenga, Priscilla C Williams, R Mark Sharp, Gene B Hubbard
Affiliations

Endometrial and cervical polyps in 22 baboons (Papio sp.), 5 cynomolgus macaques (Macaca fascicularis) and one marmoset (Callithrix jacchus)

Melissa W Bennett et al. J Med Primatol. 2009 Aug.

Abstract

Background: Endometrial and cervical polyps are masses of endometrium or cervical epithelium that bulge into the uterine or cervical lumen. The physiopathology and contributing factors of endometrial polyps development are still unknown.

Methods: Clinical and pathology records of 28 non-human primates with histologically confirmed endometrial and cervical polyps were reviewed. Twenty-one baboons with endometrial polyps were evaluated for age at diagnosis, body weight, menstrual cycle length, presence of endometriosis and adenomyosis and number of offspring, cesarean sections, and stillbirths.

Results: Endometrial polyps in baboons were associated with increased age, decreased menstrual cycle lengths, endometriosis, and decreased parity. No differences were found for weight, adenomyosis, or number of cesarean sections or stillbirths.

Conclusions: Baboons are a promising model for the study of endometrial polyps because of their similarity to humans in both the development of endometrial polyps and association of many of the same risk factors.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Endometrial polyps in baboons
A and B, Gross appearance of endometrial polyps in baboons. C and D, Subgross appearance of endometrial polyps in cynomolgus macaques (scanned histologic section, H&E).
Figure 2
Figure 2
Logistical regression of offspring for baboons with and without endometrial polyps, adjusted by age and weight.
See this image and copyright information in PMC

References

    1. Anderson MC, Robboy SJ, Russell P, Morse A. Endometritis, metaplasias, polyps, and miscellaneous changes. In: Robboy, Anderson, Russell, editors. Pathology of the Female Reproductive Tract. Churchill Livingstone; Edinburgh: 2002.
    1. Anderson MC, Robboy SJ, Russell P, Morse A. The cervix – benign and neoplastic conditions. In: Robboy, Anderson, Russell, editors. Pathology of the Female Reproductive Tract. Churchill Livingstone; Edinburgh: 2002.
    1. Baskin GB, Smith SM, Marx PA. Endometrial hyperplasia, polyps, and adenomyosis associated with unopposed estrogen in rhesus monkeys (Macaca mulatta) Vet Pathol. 2002;39:572–575. - PubMed
    1. Beniashvili DS. Experimental Tumors in Monkeys. Boca Raton: CRC Press; 1994.
    1. Bentley RC, Robboy SJ, Russell P, Anderson MC. Exogenous hormones and endometrium. In: Robboy, Anderson, Russell, editors. Pathology of the Female Reproductive Tract. Churchill Livingstone; Edinburgh: 2002.

Publication types