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Comparative Study
. 2009 Apr 15;19(8):2299-304.
doi: 10.1016/j.bmcl.2009.02.077. Epub 2009 Feb 25.

Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants

Stefano Pegoraro  1 , Martin Lang, Tobias Dreker, Jürgen Kraus, Svetlana Hamm, Cathal Meere, Juliane Feurle, Stefan Tasler, Sylvia Prütting, Zerrin Kuras, Violeta Visan, Stephan Grissmer
Affiliations
Comparative Study

Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants

Stefano Pegoraro et al. Bioorg Med Chem Lett. .

Erratum in

  • Bioorg Med Chem Lett. 2011 Sep 15;21(18):5647-8

Abstract

New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.

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