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Comment
. 2009 Mar 12;61(5):653-4.
doi: 10.1016/j.neuron.2009.02.015.

The headache of a hyperactive calcium channel

Mingshan Xue  1 , Christian Rosenmund
Affiliations
Comment

The headache of a hyperactive calcium channel

Mingshan Xue et al. Neuron. .

Abstract

Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical glutamatergic synaptic transmission as an underlying mechanism for the susceptibility of cortical spreading depression initiation in migraine disorders.

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