Comment
doi: 10.1016/j.chom.2009.02.002.
This bud's for Vpu
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- PMID: 19286130
- DOI: 10.1016/j.chom.2009.02.002
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Comment
This bud's for Vpu
Cell Host Microbe.
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Free article
Abstract
Successful viruses must overcome the body's immune defenses. In this issue of Cell Host & Microbe, Goffinet et al. (2009) provide evidence that the host protein CD317, the target of the HIV Vpu protein, is part of an ancient innate immune response directed against budding viruses.
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HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor.Cell Host Microbe. 2009 Mar 19;5(3):285-97. doi: 10.1016/j.chom.2009.01.009. Cell Host Microbe. 2009. PMID: 19286137
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