Comment
doi: 10.1016/j.devcel.2009.02.015.
Harness the power: new insights into the inhibition of YAP/Yorkie
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- PMID: 19289076
- DOI: 10.1016/j.devcel.2009.02.015
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Comment
Harness the power: new insights into the inhibition of YAP/Yorkie
Dev Cell.
2009 Mar.
Free article
Abstract
YAP/Yorkie (Yki) is a transcriptional coactivator that controls organ size; dysregulation causes tumorigenesis by stimulating cell proliferation and inhibiting apoptosis. The Hippo pathway restrains YAP/Yki activity, but it remains unclear how cellular regulation at the plasma membrane influences the Hippo-YAP/Yki pathway. Two papers in this issue on Developmental Cell, by Badouel et al. and Nishioka et al., address this question.
Comment on
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The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass.Dev Cell. 2009 Mar;16(3):398-410. doi: 10.1016/j.devcel.2009.02.003. Dev Cell. 2009. PMID: 19289085
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The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie.Dev Cell. 2009 Mar;16(3):411-20. doi: 10.1016/j.devcel.2009.01.010. Dev Cell. 2009. PMID: 19289086
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