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Review
. 2009 Mar 17;72(11):1008-15.
doi: 10.1212/01.wnl.0000344417.42972.54.

Multiple sclerosis therapeutics: unexpected outcomes clouding undisputed successes

Heinz Wiendl  1 , Reinhard Hohlfeld
Affiliations
Review

Multiple sclerosis therapeutics: unexpected outcomes clouding undisputed successes

Heinz Wiendl et al. Neurology. .

Abstract

In this essay, we draw attention to some recent downsides and surprises of multiple sclerosis (MS) therapeutics. These include experiences with recent head-to-head trials of interferon-beta and glatiramer acetate, dose escalation trials, frustrating efforts with progressive MS trials, failures of smart concepts and designer therapies, and harsh lessons from newly observed adverse reactions.

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