Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Mar 23;184(6):771-6.
doi: 10.1083/jcb.200812014. Epub 2009 Mar 16.

In search of nonribosomal nucleolar protein function and regulation

Thoru Pederson  1 , Robert Y L Tsai
Affiliations
Review

In search of nonribosomal nucleolar protein function and regulation

Thoru Pederson et al. J Cell Biol. .

Abstract

The life of the nucleolus has proven to be more colorful and multifaceted than had been envisioned a decade ago. A large number of proteins found in this subnuclear compartment have no identifiable tie either to the ribosome biosynthetic pathway or to the other newly established activities occurring within the nucleolus. The questions of how and why these proteins end up in this subnuclear compartment remain unanswered and are the focus of intense current interest. This review discusses our thoughts on the discovery of nonribosomal proteins in the nucleolus.

PubMed Disclaimer

References

    1. Alber F., Dokudovskaya S., Veenhoff L.M., Zhang W., Kipper J., Devos D., Suprapto A., Karni-Schmidt O., Williams R., Chait B.T., et al. 2007. The molecular architecture of the nuclear pore complex.Nature. 450:695–701 - PubMed
    1. Andersen J.S., Lyon C.E., Fox A.H., Leung A.K., Lam Y.W., Steen H., Mann M., Lamond A.I. 2002. Directed proteomic analysis of the human nucleolus.Curr. Biol. 12:1–11 - PubMed
    1. Andersen J.S., Lam Y.W., Leung A.K., Ong S.E., Lyon C.E., Lamond A.I., Mann M. 2005. Nucleolar proteome dynamics.Nature. 433:77–83 - PubMed
    1. Azzam R., Chen S.L., Shou W., Mah A.S., Alexandru G., Nasmyth K., Annan R.S., Carr S.A., Deshaies R.J. 2004. Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.Science. 305:516–519 - PubMed
    1. Bassermann F., Frescas D., Guardavaccaro D., Busino L., Peschiaroli A., Pagano M. 2008. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.Cell. 134:256–267 - PMC - PubMed

Publication types