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. 2009 Jun;32(6):1049-51.
doi: 10.2337/dc08-2216. Epub 2009 Mar 16.

Association of endogenous sex hormones with diabetes and impaired fasting glucose in men: multi-ethnic study of atherosclerosis

Laura A Colangelo  1 , Pamela Ouyang, Kiang Liu, Peter Kopp, Sherita Hill Golden, Adrian S Dobs, Moyses Szklo, Dhananjay Vaidya, Mary Cushman, Susan M Gapstur
Affiliations

Association of endogenous sex hormones with diabetes and impaired fasting glucose in men: multi-ethnic study of atherosclerosis

Laura A Colangelo et al. Diabetes Care. 2009 Jun.

Abstract

Objective: To assess associations of sex hormones with impaired fasting glucose (IFG) and type 2 diabetes in men.

Research design and methods: A total of 3,156 African American, Non-Hispanic white, Hispanic, and Chinese-American men aged 45-84 years who participated in the baseline visit of the Multi-Ethnic Study of Atherosclerosis (MESA) were included. Odd sratios and 95% CIs for type 2 diabetes and IFG compared with normal fasting glucose for quartiles of hormones were estimated.

Results: After adjusting for age, ethnicity, BMI, and waist circumference, IFG and diabetes were associated inversely with total testosterone and sex hormone-binding globulin (SHBG) and positively with estradiol (E2). Dehydroepiandrosterone was positively associated with IFG but not with diabetes. Associations did not differ across ethnic groups.

Conclusions: Regardless of obesity, total testosterone and SHBG were associated inversely and E2 was associated positively with IFG and diabetes in men. Further research is warranted to better understand the underlying biological mechanisms.

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References

    1. Ding EL, Song Y, Malik VS, Liu S: Sex differences of endogenous sex hormones and risk of type 2 diabetes. JAMA 2006; 295: 1288– 1299 - PubMed
    1. Selvin E, Feinleib M, Zhang L, Rohrmann S, Rifai N, Nelson WG, Dobs A, Basaria S, Golden SH, Platz EA: Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care 2007; 30: 234– 238 - PubMed
    1. Golden SH, Dobs AS, Vaidya D, Szklo M, Gapstur S, Kopp P, Liu K, Ouyang P: Endogenous sex hormones and glucose tolerance status in postmenopausal women. J ClinEndocrinol Metab 2007; 92: 1289– 1295 - PubMed
    1. Bild DE, Bluemke DA, Burke GL, Detrano R, Diez Roux AV, Folsom AR, Greenland P, Jacobs DR, Jr, Kronmal R, Liu K, Saad MF, Shea S, Szklo M, Tracy RP: Multi-Ethnic Study of Atherosclerosis: objectives and design. Am JEpidemiol 2002; 156: 871– 881 - PubMed
    1. Wang C, Christenson P, Swerdloff R: Clinical relevance of racial and ethnic differences in sex steroids (Editorial). J Clin Endocrinol Metab 2007; 92: 2433– 2435 - PubMed

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