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. 2009 Mar;28(2):137-46.
doi: 10.1037/a0012982.

Influence of stressors on breast cancer incidence in the Women's Health Initiative

Yvonne L Michael  1 , Nichole E Carlson, Rowan T Chlebowski, Mikel Aickin, Karen L Weihs, Judith K Ockene, Deborah J Bowen, Cheryl Ritenbaugh
Affiliations

Influence of stressors on breast cancer incidence in the Women's Health Initiative

Yvonne L Michael et al. Health Psychol. 2009 Mar.

Abstract

Objective: To examine associations among life events stress, social support, and breast cancer incidence in a cohort of postmenopausal women. DESIGN AND MAIN OUTCOME MEASURE: Women's Health Initiative observational study participants, breast cancer free at entry, who provided assessment of stressful life events, social support, and breast cancer risk factors, were prospectively followed for breast cancer incidence (n = 84,334).

Results: During an average of 7.6 years of follow-up, 2,481 invasive breast cancers were diagnosed. In age-adjusted proportional hazards models, 1 stressful life event was associated with increased risk, but risk decreased with each additional stressful life event. After adjustment for confounders the decreasing risk was not significant. Stressful life events and social support appeared to interact in relation to breast cancer risk such that women who had greater number of stressful life events and low social support had a decreased risk of breast cancer.

Conclusions: This study found no independent association between stressful life events and breast cancer risk. The results are compatible with a more complex model of psychosocial factors interacting in relation to breast cancer risk.

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References

    1. Alferi SM, Carver CS, Antoni MH, Weiss S, Durán RE. An exploratory study of social support, distress, and life disruption among low-income Hispanic women under treatment for early stage breast cancer. Health Psychology. 2001;20:41–46. - PubMed
    1. Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, McDonald PG, Stefanek M, Sood AK. The influence of bio-behavioral factors on tumor biology: pathways and mechanisms. Nature. 2006;6:240–248. - PMC - PubMed
    1. Bleiker EM, Van der Ploeg HM, Hendricks JH, Ader HJ. Personality factors and breast cancer development: a prospective longitudinal study. Journal of the National Cancer Institute. 1996;88:1478–82. - PubMed
    1. Butler LD, Koopman C, Classen C, Spiegel D. Traumatic stress, life events, and emotional support in women with metastatic breast cancer: cancer-related traumatic stress symptoms associated with past and current stressors. Health Psychology. 1999;18:555–60. - PubMed
    1. Butow PN, Hiller J, Price M, Thackway S, Kricker A, Tennant C. Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer. Journal of Psychosomatic Research. 2000;49:169–181. - PubMed

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