Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009;13(1):120.
doi: 10.1186/cc7704. Epub 2009 Feb 23.

Extending international sepsis epidemiology: the impact of organ dysfunction

Annette M Esper  1 , Greg S Martin
Affiliations
Review

Extending international sepsis epidemiology: the impact of organ dysfunction

Annette M Esper et al. Crit Care. 2009.

Abstract

In the previous issue of Critical Care, Blanco and colleagues contributed to a growing body of literature on the international epidemiology of severe sepsis. Taken together, these studies confirm that the sepsis incidence is high, that the development of organ dysfunction is a major determinant of mortality and that the occurrence of organ dysfunction is influenced by chronic comorbid medical conditions. It is clear that early detection of organ dysfunction and serial sequential organ dysfunction scoring provides us with the best chance to optimize clinical care. Identifying factors that contribute to the development of organ dysfunction in sepsis will lead to the development of new treatment modalities that will reduce mortality. Future studies must therefore focus on the impact of new treatment modalities for preventing progression to multiple organ dysfunction syndrome and consequent mortality in sepsis.

PubMed Disclaimer

Comment on

  • Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study.
    Blanco J, Muriel-Bombín A, Sagredo V, Taboada F, Gandía F, Tamayo L, Collado J, García-Labattut A, Carriedo D, Valledor M, De Frutos M, López MJ, Caballero A, Guerra J, Alvarez B, Mayo A, Villar J; Grupo de Estudios y Análisis en Cuidados Intensivos. Blanco J, et al. Crit Care. 2008;12(6):R158. doi: 10.1186/cc7157. Epub 2008 Dec 17. Crit Care. 2008. PMID: 19091069 Free PMC article.

References

    1. Blanco J, Muriel-Bombín A, Sagredo V, Taboada F, Gandía F, Tamayo L, Collado J, García-Labattut , Carriedo D, Valledor M, De Frutos M, López MJ, Caballero A, Guerra J, Álvarez B, Mayo A, Villar J, the Grupo de Estudios y Análisis en Cuidados Intensivos (G.R.E.C.I.A.) Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicenter study. Crit Care. 2008;12:R158. - PMC - PubMed
    1. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546–1554. doi: 10.1056/NEJMoa022139. - DOI - PubMed
    1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303–1310. doi: 10.1097/00003246-200107000-00002. - DOI - PubMed
    1. Harrison DA, Welch CA, Eddleston JM. The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database. Crit Care. 2006;10:R42. doi: 10.1186/cc4854. - DOI - PMC - PubMed
    1. Brun-Buisson C, Doyon F, Carlet J, Dellamonica P, Gouin F, Lepoutre A, Mercier JC, Offenstadt G, Regnier B. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis. JAMA. 1995;274:968–974. doi: 10.1001/jama.274.12.968. - DOI - PubMed

MeSH terms