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. 1991 Jun;35(6):1219-24.
doi: 10.1128/AAC.35.6.1219.

Effect of beta-lactamase inhibitors on the activities of various beta-lactam agents against anaerobic bacteria

H M Wexler  1 , E Molitoris, S M Finegold
Affiliations

Effect of beta-lactamase inhibitors on the activities of various beta-lactam agents against anaerobic bacteria

H M Wexler et al. Antimicrob Agents Chemother. 1991 Jun.

Abstract

The in vitro activities of several new beta-lactam-beta-lactamase inhibitor combinations (piperacillin plus tazobactam, ceftizoxime and cefonicid with sulbactam and clavulanic acid, and ampicillin plus 8 micrograms of sulbactam per ml) were tested with anaerobic bacteria and compared with known beta-lactam-beta-lactamase inhibitor combinations and other potent antianaerobe agents. All the combinations tested (except for the cefonicid-inhibitor combinations) were active against almost all strains of the Bacteroides fragilis group. This report indicates that beta-lactamase inhibitors may improve the activity of beta-lactam agents with marginal activity against the B. fragilis group.

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References

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