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. 1991 Jun;35(6):1243-4.
doi: 10.1128/AAC.35.6.1243.

Efficacy of different beta-lactams against an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strain in the rat intra-abdominal abscess model

L B Rice  1 , J D Yao, K Klimm, G M Eliopoulos, R C Moellering Jr
Affiliations

Efficacy of different beta-lactams against an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strain in the rat intra-abdominal abscess model

L B Rice et al. Antimicrob Agents Chemother. 1991 Jun.

Abstract

Although standard-inoculum MICs were within the susceptible range for all compounds, cefoperazone, cefotaxime, and cefpirome were significantly less effective than imipenem or the combination of cefoperazone and sulbactam in the treatment of rat intra-abdominal abscesses due to an extended-spectrum beta-lactamase-producing strain of Klebsiella pneumoniae.

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