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Comment
. 2009 Mar 24;106(12):4579-80.
doi: 10.1073/pnas.0901519106. Epub 2009 Mar 17.

Endocannabinoids: The silent partner of glucocorticoids in the synapse

Matthew N Hill  1 , Bruce S McEwen
Affiliations
Comment

Endocannabinoids: The silent partner of glucocorticoids in the synapse

Matthew N Hill et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Corticosterone (CORT) binds to a yet-uncharacterized membrane-bound glucocorticoid receptor (mbGR) that activates the Gs–cAMP/PKA pathway to induce endocannabinoid (eCB) synthesis. Endocannabinoids are released into the synapse where they bind to CB1 receptors on GABAergic terminals inhibiting GABA release. This inhibition of GABA release disinhibits norepinephrine (NE) release and increases NE activation of postsynaptic β-adrenoreceptors, increasing the consolidation of emotionally-aversive memories.
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