Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Aug;35(8):1669-71.
doi: 10.1128/AAC.35.8.1669.

Interactions of amphotericin B and SCH 39304 in the treatment of experimental murine candidiasis: lack of antagonism of a polyene-azole combination

A M Sugar  1
Affiliations

Interactions of amphotericin B and SCH 39304 in the treatment of experimental murine candidiasis: lack of antagonism of a polyene-azole combination

A M Sugar. Antimicrob Agents Chemother. 1991 Aug.

Abstract

Mice infected intravenously with Candida albicans were treated with SCH 39304, a new triazole antifungal compound, amphotericin B, or both. Two dose levels of each drug were evaluated in an attempt to identify potential helpful or harmful effects on survival and kidney colony counts. Contrary to theoretical predictions, combination therapy was not antagonistic and some additive or synergistic effects were observed. The results obtained in this study suggest that antagonism between polyene and azole antifungal drugs is not inevitable and that additive or synergistic effects may be possible.

PubMed Disclaimer

References

    1. J Infect Dis. 1985 May;151(5):902-10 - PubMed
    1. Antimicrob Agents Chemother. 1989 Aug;33(8):1242-6 - PubMed
    1. Antimicrob Agents Chemother. 1989 Oct;33(10):1735-40 - PubMed
    1. J Clin Pharmacol. 1990 Jul;30(7):638-42 - PubMed
    1. Antimicrob Agents Chemother. 1990 Apr;34(4):524-8 - PubMed

Publication types