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Comment
. 2009:5:251.
doi: 10.1038/msb.2009.7. Epub 2009 Mar 17.

Toward a comprehensive and quantitative understanding of intracellular microtubule organization

Ekaterina L Grishchuk
Comment

Toward a comprehensive and quantitative understanding of intracellular microtubule organization

Ekaterina L Grishchuk. Mol Syst Biol. 2009.
No abstract available

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Figures

Figure 1
Figure 1
3D organization and spatial regulation of microtubule cytoskeleton in fission yeast. (A) Intracellular architecture of S. pombe cell, as viewed with 3D simulation (reproduced from Foethke et al, 2009). (B, C) Spatially resolved measurements of catastrophe frequency in wild type and klp5Δklp6Δ cells as a function of distance to the cell center (x) in cells with different half lengths L (reproduced from Tischer et al, 2009). Darker red colors correspond to more frequent catastrophes. In wild-type cells with various lengths, microtubules inevitably undergo catastrophe after contacting the cell end (the diagonal darker area on (B)), but in elongated cells longer microtubules are destabilized even when their tips are ⩾1 μm away from cell end (red-colored area at the right lower corner of the graph). Deletion of Klp5/6 motors (C) leads to a loss of this long-range regulation and also reduces the strength of a cortex-dependent effects.
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