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. 2009 Mar;50(3):392-400.
doi: 10.1080/10428190902741471.

Diagnostic delay and complications for older adults with multiple myeloma

Christopher R Friese  1 , Gregory A Abel, Lysa S Magazu, Bridget A Neville, Lisa C Richardson, Craig C Earle
Affiliations

Diagnostic delay and complications for older adults with multiple myeloma

Christopher R Friese et al. Leuk Lymphoma. 2009 Mar.

Abstract

Increased attention to timely diagnosis motivated us to study 5483 patients diagnosed with multiple myeloma using Medicare claims linked to tumor registries in the Surveillance, Epidemiology and End Results programme. We calculated the time between initial visits for anemia or back pain and for myeloma diagnosis, and used logistic regression to predict the likelihood of diagnostic delay, and also the likelihood of renal or skeletal complications. The median time between sign or symptom and myeloma diagnosis was 99 days. Patients with anemia, back pain and comorbidities were more likely to experience diagnostic delay (OR 1.6, 95% CI 1.3-2.0). Diagnosis while hospitalised (OR 2.5, 95% CI 2.2-2.9) and chemotherapy treatment within 6 months of diagnosis (OR 1.4, 95% CI 1.2-1.6) significantly predicted complications; diagnostic delay did not (OR 0.9, 95% CI 0.8-1.1). Our data suggest that complications are more strongly associated with health status and myeloma severity than with diagnostic delays.

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Figures

Figure 1
Figure 1
Frequency of pre-diagnosis signs, symptoms and procedures (n = 5483). The majority of study patients experienced anemia or had a transfusion of PRBCs prior to myeloma diagnosis. Less than 25% of patients had PEP and bone marrow biopsy prior to diagnosis.
See this image and copyright information in PMC

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