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Comment
. 2009 Mar 18;28(6):619-20.
doi: 10.1038/emboj.2009.50.

Long-range signalling in activation of the translational GTPase EF-Tu

Affiliations
Comment

Long-range signalling in activation of the translational GTPase EF-Tu

Marina V Rodnina. EMBO J. .
No abstract available

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Figures

Figure 1
Figure 1
Sequence of steps during GTPase activation. For explanations, see text. The distortion of aa-tRNA is indicated by a kink. E, P, A, tRNA binding sites of the ribosome. GTP* denotes the GTPase-activated conformation of EF-Tu. The structure of the kirromycin-stabilized intermediate indicated by the red frame was solved by cryo-EM.

Comment on

References

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    1. Daviter T, Wieden HJ, Rodnina MV (2003) Essential role of histidine 84 in elongation factor Tu for the chemical step of GTP hydrolysis on the ribosome. J Mol Biol 332: 689–699 - PubMed
    1. Kothe U, Rodnina MV (2006) Delayed release of inorganic phosphate from elongation factor Tu following GTP hydrolysis on the ribosome. Biochemistry 45: 12767–12774 - PubMed
    1. Marshall RA, Aitken CE, Dorywalska M, Puglisi JD (2008) Translation at the single-molecule level. Annu Rev Biochem 77: 177–203 - PubMed
    1. Ogle JM, Ramakrishnan V (2005) Structural insights into translational fidelity. Annu Rev Biochem 74: 129–177 - PubMed

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