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Review
. 2009 Apr;85(4):359-61.
doi: 10.1038/clpt.2009.6.

Genes and addictions

L Bevilacqua  1 , D Goldman
Affiliations
Review

Genes and addictions

L Bevilacqua et al. Clin Pharmacol Ther. 2009 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST

The authors declared no conflict of interest.

Figures

Figure 1
Figure 1
Heritability (weighted mean and range) of 10 addictive disorders: dependence on or abuse of hallucinogens, stimulants, cannabis, sedatives, opiates, and cocaine; alcohol dependence; smoking persistence; caffeine consumption or heavy use; and pathological gambling. Weighted heritability means were computed using data from large national surveys of adult twins. Reprinted from ref. .
Figure 2
Figure 2
Multiple avenues for identification of gene targets in addictions (top), in human and in animal models, have been taken by multilevel studies (center), leading to the discovery of functional alleles. The genes and loci listed in the table are examples of mechanistic domains in which functional vulnerability alleles have been identified. GWAS, genome-wide association studies; mRNA, messenger RNA; QTLs, quantitative trait loci.
See this image and copyright information in PMC

References

    1. Koob GF. A role for brain stress systems in addiction. Neuron. 2008;59:11–34. - PMC - PubMed
    1. Everitt BJ, Belin D, Economidou D, Pelloux Y, Dalley JW, Robbins TW. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Phil. Trans. R. Soc. B. 2008;363:3125–3135. - PMC - PubMed
    1. Goldman D, Oroszi G, Ducci F. The genetics of addiction: uncovering the genes. Nat. Rev. Genet. 2005;6:521–532. - PubMed
    1. Kendler KS, Schmitt E, Aggen SH, Prescott CA. Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood. Arch. Gen. Psychiatry. 2008;65:674–682. - PMC - PubMed
    1. Anton RF, Oroszi G, O'Malley S, Couper D, Swift R, Pettinati H, et al. An evaluation of μ-opioid receptor (OPRM1) I as a predictor of naltrexone response in the treatment of alcohol dependence. Arch. Gen. Psychiatry. 2008;65:135–144. - PMC - PubMed

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