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Randomized Controlled Trial
. 2009 Jul;14(3):356-65.
doi: 10.1111/j.1369-1600.2009.00149.x. Epub 2009 Mar 5.

Do genetic and individual risk factors moderate the efficacy of motivational enhancement therapy? Drinking outcomes with an emerging adult sample

Sarah W Feldstein Ewing  1 , Heather A LaChance, Angela Bryan, Kent E Hutchison
Affiliations
Randomized Controlled Trial

Do genetic and individual risk factors moderate the efficacy of motivational enhancement therapy? Drinking outcomes with an emerging adult sample

Sarah W Feldstein Ewing et al. Addict Biol. 2009 Jul.

Abstract

Research indicates that motivational enhancement therapy (MET) helps catalyze reductions in problem drinking among emerging adults. However, moderators of this intervention remain relatively unknown. Therefore, the objectives of this study were: (1) to test whether a single session of MET increased motivation to reduce drinking and drinking outcomes; and (2) to examine whether genetic dopamine D(4) receptor L (DRD4 L) and individual personality risk factors (impulsivity and novelty seeking) moderated the effects of the MET. These hypotheses were evaluated by randomly assigning a sample of emerging adult problem drinkers (n = 67) to receive a single session of MET or alcohol education. Follow-up data indicated that only individuals who were low in impulsivity, novelty seeking and/or who had the short DRD4 variable number of tandem repeats genotype evidenced differentially increased behavior change (taking steps toward reducing drinking) following the MET.

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Figures

Figure 1
Figure 1
Intervention effects by DRD4 VNTR genotype in the alcohol education (AE) control and motivational enhancement therapy (MET) conditions. (a) DRD4 S individuals. (b) DRD4 L individuals
Figure 2
Figure 2
Intervention effects by level of impulsivity/sensation-seeking in the alcohol education (AE) control and motivational enhancement therapy (MET) conditions. (a) Low impulsivity/ sensation seeking. (b) High impulsivity/sensation seeking
See this image and copyright information in PMC

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