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Meta-Analysis
. 2010 Apr;14(4):944-53.
doi: 10.1111/j.1582-4934.2009.00730.x. Epub 2010 Feb 27.

p27(Kip1) as a prognostic factor in breast cancer: a systematic review and meta-analysis

Xiaoxiang Guan  1 , Yucai Wang, Ruilian Xie, Longbang Chen, Jianling Bai, Jia Lu, Macus Tien Kuo
Affiliations
Meta-Analysis

p27(Kip1) as a prognostic factor in breast cancer: a systematic review and meta-analysis

Xiaoxiang Guan et al. J Cell Mol Med. 2010 Apr.

Abstract

The aim of this study was to comprehensively evaluate via a meta-analysis the association between p27 expression and clinical outcome in breast cancer patients. We conducted a meta-analysis of 20 studies (n= 6463 patients) that evaluated the correlation between p27 expression and indicators of breast cancer clinical outcome, including overall survival (OS), disease-free survival (DFS) and relapse-free survival (RFS). Data pooling was performed by RevMan 4.2. A total of 60% (9 of 15) of the studies showed a significant association between p27 high expression and OS, whereas 25% (2 of 8) and 60% (3 of 5) studies demonstrated a correlation between p27 high expression and DFS and RFS, respectively. The relative risks (RRs) were 1.34 (1.26-1.42) for OS (P < 0.00001), 1.27 (1.10-1.47) for DFS (P= 0.001) and 1.49 (0.92-2.42) for RFS (P= 0.10). In lymph node-negative breast cancer patients, the RRs for OS and RFS were 1.84 (1.30-2.59; P= 0.0005) and 1.30 (0.20-8.50; P= 0.78), respectively. In lymph node-positive breast cancer patients, the RRs for OS and RFS were 2.99 (1.77-5.07; P < 0.0001) and 1.49 (0.80-2.77; P= 0.21), respectively. This meta-analysis indicates that reduced p27 is an independent prognostic factor for poor overall and disease-free cancer survival.

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Figures

Fig 1
Fig 1
Methodological flow chart of the systematic review.
Fig 2
Fig 2
Forest plots of risk ratios (RRs) for survival in breast cancer patients. (A) RR for overall survival (OS); (B) RR for disease-free survival (DFS) and (C) RR for relapse-free survival (RFS). William 2004, Merav 2005, and Shinichi 2006 refer to Foulkes 2004 [Ref. 33], Slotky 2005 [Ref. 35], and Tsutsui 2006 [Ref. 38] in Table 2, respectively.
Fig 2
Fig 2
Forest plots of risk ratios (RRs) for survival in breast cancer patients. (A) RR for overall survival (OS); (B) RR for disease-free survival (DFS) and (C) RR for relapse-free survival (RFS). William 2004, Merav 2005, and Shinichi 2006 refer to Foulkes 2004 [Ref. 33], Slotky 2005 [Ref. 35], and Tsutsui 2006 [Ref. 38] in Table 2, respectively.
Fig 2
Fig 2
Forest plots of risk ratios (RRs) for survival in breast cancer patients. (A) RR for overall survival (OS); (B) RR for disease-free survival (DFS) and (C) RR for relapse-free survival (RFS). William 2004, Merav 2005, and Shinichi 2006 refer to Foulkes 2004 [Ref. 33], Slotky 2005 [Ref. 35], and Tsutsui 2006 [Ref. 38] in Table 2, respectively.
Fig 3
Fig 3
Forest plots of RRs for OS and DFS in breast cancer patients who received adjuvant treatment.
See this image and copyright information in PMC

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