Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 May;30(5):917-22.
doi: 10.3174/ajnr.A1513. Epub 2009 Mar 19.

C-arm CT measurement of cerebral blood volume: an experimental study in canines

A S Ahmed  1 , M Zellerhoff, C M Strother, K A Pulfer, T Redel, Y Deuerling-Zheng, K Royalty, D Consigny, D B Niemann
Affiliations

C-arm CT measurement of cerebral blood volume: an experimental study in canines

A S Ahmed et al. AJNR Am J Neuroradiol. 2009 May.

Abstract

Background and purpose: Cerebral blood volume (CBV) is an important parameter in estimating the viability of brain tissue following an ischemic event. We tested the hypothesis that C-arm CT measurements of CBV would correlate well with those made with perfusion CT (PCT).

Materials and methods: CBV was measured in 12 canines by using PCT and C-arm CT. Two measurements with each technique were made on each animal; a different injection protocol was used for each of these techniques. PCT was performed by using a 64-section V-scanner. C-arm CT was performed by using a biplane Artis dBA system. PCT images were transferred to a commercially available workstation for postprocessing and analysis; C-arm CT images were transferred to a commercially available workstation for postprocessing and analysis by using prototype software. From each animal, 2 sections from each technique were selected for analysis.

Results: There was good agreement of both the color maps and absolute numbers between the 2 techniques. The maximum and mean deviations of values between the 2 techniques for the first 5 animals were 30.20% and 7.82%; for the second 7 animals, these values were 26.79% and 7.40%. The maximum and mean deviations between the 2 C-arm CT studies performed on the first 5 animals were 33.15% and 12.24%; for the second 7 animals, these values were 41.15% and 10.89%.

Conclusions: In these healthy animals, measurement of CBV with C-arm CT compared well with measurements made with PCT.

PubMed Disclaimer

Figures

Fig 1.
Fig 1.
Diagram showing the postprocessing scheme used to obtain the C-arm CT CBV maps. Recon indicates reconstruction.
Fig 2.
Fig 2.
Average region of interest CBV values for C-arm and PCT studies.
Fig 3.
Fig 3.
Bland-Altman plot showing the relationship of the difference of CTP–C-arm CT CBV versus the average CT and C-arm CBV. Bias is −.20 mL/100 g. Limits of agreement are −.20 ± 1.03 mL/100 g.
Fig 4.
Fig 4.
C-arm and PCT CBV maps from animal 1.
Fig 5.
Fig 5.
C-arm and PCT CBV maps from animal 2.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke: the PROACT II study—a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 1999;282:2003–11 - PubMed
    1. IMS II Trial Investigators. The Interventional Management of Stroke (IMS) II Study. Stroke 2007;38:2127–35. Epub 2007 May 24 - PubMed
    1. Chalela JA, Kidwell CS, Nentwich LM, et al. Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet 2007;369:293–98 - PMC - PubMed
    1. Hamberg LM, Hunter GJ, Kierstead D, et al. Measurement of cerebral blood volume with subtraction three-dimensional functional CT. AJNR Am J Neuroradiol 1996;17:1861–69 - PMC - PubMed
    1. Wintermark M, Flanders AE, Velthuis B, et al. Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke 2006;37:979–85 - PubMed

Publication types

MeSH terms