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Multicenter Study
. 2009 May 15;23(8):1021-4.
doi: 10.1097/QAD.0b013e3283292195.

Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults

Fidéline Collin  1 , Xavier Duval, Vincent Le Moing, Lionel Piroth, Firas Al Kaied, Patrice Massip, Virginie Villes, Geneviève Chêne, François Raffi; ANRS CO8 APROCO-COPILOTE study group
Collaborators, Affiliations
Multicenter Study

Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults

Fidéline Collin et al. AIDS. .

Abstract

In the ANRS CO8 APROCO-COPILOTE cohort of patients treated with combination antiretroviral therapy since 1997-1999, the incidence density of bone fractures was 3.3 for 1000 patient-years [95% confidence interval (CI) = 2.0-4.6]. The rate was 2.9-fold (95% CI = 1.3-6.5) higher among patients with excessive alcohol consumption and 3.6-fold (95% CI = 1.6-8.1) higher in those with hepatitis C virus (HCV) coinfection. Specific monitoring of HCV/HIV-coinfected patients and active promotion of alcohol cessation should be recommended for the prevention of bone fractures.

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Figures

Figure 1
Figure 1
Cumulated probability of a first fracture estimated by the Kaplan-Meier method, ANRS CO8 APROCO-COPILOTE cohort (1997–2007).
See this image and copyright information in PMC

References

    1. Tebas P, Powderly WG, Claxton S, Marin D, Tantisiriwat W, Teitelbaum SL, et al. Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy. Aids. 2000;14(4):F63–7. - PMC - PubMed
    1. Negredo E, Martinez E, Cinquegrana D, Estany C, Clotet B. Therapeutic management of bone demineralization in the HIV-infected population. Aids. 2007;21(6):657–63. - PubMed
    1. Thomas J, Doherty SM. HIV infection—a risk factor for osteoporosis. J Acquir Immune Defic Syndr. 2003;33(3):281–91. - PubMed
    1. Bruera D, Luna N, David DO, Bergoglio LM, Zamudio J. Decreased bone mineral density in HIV-infected patients is independent of antiretroviral therapy. Aids. 2003;17(13):1917–23. - PubMed
    1. Arnsten JH, Freeman R, Howard AA, Floris-Moore M, Lo Y, Klein RS. Decreased bone mineral density and increased fracture risk in aging men with or at risk for HIV infection. Aids. 2007;21(5):617–23. - PMC - PubMed

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