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. 2009 Jun;4(6):963-6.
doi: 10.1002/cmdc.200900011.

Fragment-based identification of Hsp90 inhibitors

John J Barker  1 , Oliver Barker, Roberto Boggio, Viddhata Chauhan, Robert K Y Cheng, Vincent Corden, Stephen M Courtney, Neil Edwards, Virginie M Falque, Fulvia Fusar, Mihaly Gardiner, Estelle M N Hamelin, Thomas Hesterkamp, Osamu Ichihara, Richard S Jones, Owen Mather, Ciro Mercurio, Saverio Minucci, Christian A G N Montalbetti, Annett Müller, Deepti Patel, Banu G Phillips, Mario Varasi, Mark Whittaker, Dirk Winkler, Christopher J Yarnold
Affiliations

Fragment-based identification of Hsp90 inhibitors

John J Barker et al. ChemMedChem. 2009 Jun.

Abstract

Heat shock protein 90 (Hsp90) plays a key role in stress response and protection of the cell against the effects of mutation. Herein we report the identification of an Hsp90 inhibitor identified by fragment screening using a high-concentration biochemical assay, as well as its optimisation by in silico searching coupled with a structure-based drug design (SBDD) approach.

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