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Comparative Study
. 1991 Sep 30;179(3):1255-8.
doi: 10.1016/0006-291x(91)91707-j.

Determination of the 5' exon structure of the human cardiac alpha-myosin heavy chain gene

N J Brand  1 , N Dabhade, M Yacoub, P J Barton
Affiliations
Comparative Study

Determination of the 5' exon structure of the human cardiac alpha-myosin heavy chain gene

N J Brand et al. Biochem Biophys Res Commun. .

Abstract

We have deduced the exon structure of the 5' untranslated region of the human cardiac alpha-myosin heavy chain gene by cloning a cDNA for this region using the polymerase chain reaction. Comparison of the cDNA and genomic DNA sequences demonstrates that the 5' non-coding region of the alpha-myosin heavy chain gene is interrupted by two introns of 645 and 337 nucleotides. Secondly we have identified the transcriptional start-site by primer extension, corroborating the previous putative assignment for the alpha-myosin heavy chain promoter based on comparisons between the rat and human genes.

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