Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Mar 20;30(3):320-1.
doi: 10.1016/j.immuni.2009.03.001.

Live from the liver: hepatocyte IL-7

Scott K Durum  1 , Renata I Mazzucchelli
Affiliations
Comment

Live from the liver: hepatocyte IL-7

Scott K Durum et al. Immunity. .

Abstract

Interleukin 7 (IL-7), which is required for T cell survival, was previously found in lymphoid tissues. In this issue of Immunity, Sawa et al. (2009) have identified the liver as a new source of IL-7.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Triggering of Several Different TLRs in an Unknown Cell Type Induces Type I IFN Expression via the TRIF Signaling Pathway
Type I IFN acts on hepatocytes, inducing IL-7 expression and release. IL-7 then prolongs the survival of naive and memory T cells.
See this image and copyright information in PMC

Comment on

References

    1. Ariizumi K, Meng Y, Bergstresser PR, Takashima A. J Immunol. 1995;154:6031–6039. - PubMed
    1. Bebo BF, Jr, Schuster JC, Adlard K, Vandenbark AA, Offner H. Cytokine. 2000;12:324–331. - PubMed
    1. Mazzucchelli R, Durum SK. Nat Rev Immunol. 2007;7:144–154. - PubMed
    1. Min D, Taylor PA, Panoskaltsis-Mortari A, Chung B, Danilenko DM, Farrell C, Lacey DL, Blazar BR, Weinberg KI. Blood. 2002;99:4592–4600. - PubMed
    1. Oshima S, Nakamura T, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Aida M, Yamaguchi Y, et al. Mol Cell Biol. 2004;24:6298–6310. - PMC - PubMed