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Review
. 2009 May 1;8(9):1352-8.
doi: 10.4161/cc.8.9.8255. Epub 2009 May 23.

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches

Giovanni Ligresti  1 , Loredana Militello, Linda S Steelman, Andrea Cavallaro, Francesco Basile, Ferdinando Nicoletti, Franca Stivala, James A McCubrey, Massimo Libra
Affiliations
Review

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches

Giovanni Ligresti et al. Cell Cycle. .

Abstract

Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling pathways involved in cell proliferation, adhesion, survival and motility. The PI3K pathway is considered to play an important role in tumorigenesis. Activating mutations of the p110alpha subunit of PI3K (PIK3CA) have been identified in a broad spectrum of tumors. Analyses of PIK3CA mutations reveals that they increase the PI3K signal, stimulate downstream Akt signaling, promote growth factor-independent growth and increase cell invasion and metastasis. In this review, we analyze the contribution of the PIK3CA mutations in cancer, and their possible implications for diagnosis and therapy.

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Figures

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Figure 1. Description of PIK3CA and its functional domains with the most common somatic mutations.
See this image and copyright information in PMC

References

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