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Review
. 2009 Jul;1793(7):1115-27.
doi: 10.1016/j.bbamcr.2009.03.004. Epub 2009 Mar 21.

Syk and pTyr'd: Signaling through the B cell antigen receptor

Robert L Geahlen  1
Affiliations
Review

Syk and pTyr'd: Signaling through the B cell antigen receptor

Robert L Geahlen. Biochim Biophys Acta. 2009 Jul.

Abstract

The B cell receptor (BCR) transduces antigen binding into alterations in the activity of intracellular signaling pathways through its ability to recruit and activate the cytoplasmic protein-tyrosine kinase Syk. The recruitment of Syk to the receptor, its activation and its subsequent interactions with downstream effectors are all regulated by its phosphorylation on tyrosine. This review discusses our current understanding of how this phosphorylation regulates the activity of Syk and its participation in signaling through the BCR.

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Figures

Fig. 1
Fig. 1
Model of Syk showing approximate locations of major sites of tyrosine-phosphorylation.
Fig. 2
Fig. 2
A stick representation (magenta) of the Syk linker B peptide showing the two phosphoryl groups by ball-and-sticks (blue). The pY342 residue is on the right and pY346 on the left. The SH2 domain is shown using a solvent accessible surface representation where the contact region within 5 angstrom of the peptide is colored tan.
See this image and copyright information in PMC

References

    1. Campbell KS, Cambier JC. B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide-linked, inducibly phosphorylated glycoprotein complex. EMBO J. 1990;9:441–448. - PMC - PubMed
    1. Cambier JC, Pleiman CM, Clark MR. Signal transduction by the B cell antigen receptor and its coreceptors. Annu Rev Immunol. 1994;12:457–486. - PubMed
    1. Gold MR, Law DA, DeFranco AL. Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor. Nature. 1990;345:810–813. - PubMed
    1. Campbell MA, Sefton BM. Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with antiimmunoglobulin. EMBO J. 1990;9:2125–2131. - PMC - PubMed
    1. DeFranco AL. The complexity of signaling pathways activated by the BCR. Curr Opin Immunol. 1997;9:296–308. - PubMed

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