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Randomized Controlled Trial
. 2009 Jun;53(6):2672-6.
doi: 10.1128/AAC.01504-08. Epub 2009 Mar 23.

Long-term follow-up trial of oral rifampin-cotrimoxazole combination versus intravenous cloxacillin in treatment of chronic staphylococcal osteomyelitis

G Euba  1 , O Murillo, N Fernández-Sabé, J Mascaró, J Cabo, A Pérez, F Tubau, R Verdaguer, F Gudiol, J Ariza
Affiliations
Randomized Controlled Trial

Long-term follow-up trial of oral rifampin-cotrimoxazole combination versus intravenous cloxacillin in treatment of chronic staphylococcal osteomyelitis

G Euba et al. Antimicrob Agents Chemother. 2009 Jun.

Abstract

Oral therapies alternative to fluoroquinolones against staphylococcal chronic osteomyelitis have not been evaluated in comparative studies. Consecutive nonaxial Staphylococcus aureus chronic osteomyelitis cases were included in a comparative trial after debridement. Fifty patients were randomized: group A (n = 22) was treated with cloxacillin for 6 weeks intravenously plus 2 weeks orally (p.o.), and group B (n = 28) was treated with rifampin-cotrimoxazole for 8 weeks p.o. During follow-up (10 years), five relapses occurred: two (10%) in group A and three (11%) in group B. Foreign-body maintenance was associated with relapse (P = 0.016). Oral rifampin-cotrimoxazole treatment showed outcomes comparable to those for intravenous cloxacillin treatment.

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