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. 2009 Apr 7;119(13):1728-35.
doi: 10.1161/CIRCULATIONAHA.108.829176. Epub 2009 Mar 23.

Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005

Sarah Rosner Preis  1 , Shih-Jen Hwang, Sean Coady, Michael J Pencina, Ralph B D'Agostino Sr, Peter J Savage, Daniel Levy, Caroline S Fox
Affiliations

Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005

Sarah Rosner Preis et al. Circulation. .

Abstract

Background: Despite population declines in all-cause mortality, women with diabetes mellitus may have experienced an increase in mortality rates compared with men.

Methods and results: We examined change in all-cause, cardiovascular, and non-cardiovascular disease mortality rates among Framingham Heart Study participants who attended examinations during an "earlier" (1950 to 1975; n=930 deaths) and a "later" (1976 to 2001; n=773 deaths) time period. Diabetes mellitus was defined as casual glucose > or =200 mg/dL, fasting plasma glucose > or =126 mg/dL, or treatment. Among women, the hazard ratios (HRs) for all-cause mortality in the later versus the earlier time period were 0.59 (95% confidence interval, 0.50 to 0.70; P<0.0001) for those without diabetes mellitus and 0.48 (95% confidence interval, 0.32 to 0.71; P=0.002) for those with diabetes mellitus. Similar results were observed in men. Among women and men, the HR of cardiovascular disease mortality declined among those with and without diabetes mellitus. Non-cardiovascular disease mortality declined among women without diabetes mellitus (HR, 0.76; P=0.01), whereas no change was observed among women with diabetes mellitus or among men with or without diabetes mellitus. Individuals with versus those without diabetes mellitus were at increased risk of all-cause mortality in the earlier (HR, 2.44; P<0.0001) and later (HR, 1.95; P<0.0001) time periods.

Conclusions: Reductions in all-cause mortality among women and men with diabetes mellitus have occurred over time. However, mortality rates among individuals with diabetes mellitus remain approximately 2-fold higher compared with individuals without diabetes mellitus.

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Figures

Figure 1
Figure 1
Figure 1a. Age-adjusted all-cause mortality rates among participants with and without diabetes, by sex and time period. Figure 1b. Age-adjusted cardiovascular disease (CVD) mortality rates among participants with and without diabetes, by sex and time period.
Figure 1
Figure 1
Figure 1a. Age-adjusted all-cause mortality rates among participants with and without diabetes, by sex and time period. Figure 1b. Age-adjusted cardiovascular disease (CVD) mortality rates among participants with and without diabetes, by sex and time period.
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References

    1. Cooper R, Cutler J, svigne-Nickens P, Fortmann SP, Friedman L, Havlik R, Hogelin G, Marler J, McGovern P, Morosco G, Mosca L, Pearson T, Stamler J, Stryer D, Thom T. Trends and disparities in coronary heart disease, stroke, and other cardiovascular diseases in the United States: findings of the national conference on cardiovascular disease prevention. Circulation. 2000;102:3137–3147. - PubMed
    1. Rosamond WD, Chambless LE, Folsom AR, Cooper LS, Conwill DE, Clegg L, Wang CH, Heiss G. Trends in the incidence of myocardial infarction and in mortality due to coronary heart disease, 1987 to 1994. N Engl J Med. 1998;339:861–867. - PubMed
    1. Fox CS, Coady S, Sorlie PD, Levy D, Meigs JB, D'Agostino RB, Sr, Wilson PW, Savage PJ. Trends in cardiovascular complications of diabetes. JAMA. 2004;292:2495–2499. - PubMed
    1. Gregg EW, Gu Q, Cheng YJ, Narayan KM, Cowie CC. Mortality trends in men and women with diabetes, 1971 to 2000. Ann Intern Med. 2007;147:149–155. - PubMed
    1. Gu K, Cowie CC, Harris MI. Diabetes and decline in heart disease mortality in US adults. JAMA. 1999;281:1291–1297. - PubMed

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