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Case Reports
. 2009 Mar 24;72(12):1101-3.
doi: 10.1212/01.wnl.0000345066.57745.50.

NMO-IgG detected in CSF in seronegative neuromyelitis optica

Affiliations
Case Reports

NMO-IgG detected in CSF in seronegative neuromyelitis optica

E C Klawiter et al. Neurology. .
No abstract available

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Figures

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Figure Neuroimaging of CSF antibody-positive neuromyelitis optica Case 1: Sagittal T2-weighted STIR MRI (A) shows hyperintensity throughout the cervical and thoracic spinal cord. Axial T1-weighted postgadolinium MRI at the level C2 (B) shows dorsal enhancement and at level C2–3 (C) shows peripheral enhancement and a central T1-weighted hypointensity. Case 2: Sagittal T2-weighted STIR MRI (D) shows hyperintensity from the lower medulla caudally with enhancement on T1-weighted postgadolinium MRI (E). Case 3: Axial T2-weighted MRI at successive levels C2 (F), C3 (G), and C4 (H) show central gray matter involvement.

References

    1. Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. Lancet Neurol 2007;6:805–815. - PubMed
    1. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 2005;202:473–477. - PMC - PubMed
    1. Weinshenker BG, Wingerchuk DM, Vukusic S, et al. Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis. Ann Neurol 2006;59:566–569. - PubMed
    1. Matiello M, Lennon VA, Jacob A, et al. NMO-IgG predicts the outcome of recurrent optic neuritis. Neurology 2008;70:2197–2200. - PubMed
    1. Wingerchuk DM, Lennon VA, Pittock SJ, Lucchinetti CF, Weinshenker BG. Revised diagnostic criteria for neuromyelitis optica. Neurology 2006;66:1485–1489. - PubMed

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