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. 2008 Dec;1(1):1-11.
doi: 10.1007/s12307-008-0001-8. Epub 2008 Jan 31.

Metastasis suppressors and the tumor microenvironment

Thomas M Bodenstine  1 , Danny R Welch
Affiliations

Metastasis suppressors and the tumor microenvironment

Thomas M Bodenstine et al. Cancer Microenviron. 2008 Dec.

Abstract

The most dangerous attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact with other tumor cells, host cells and extracellular molecules. This brief review explores how a new class of molecules - metastasis suppressors - regulate tumor cell-microenvironmental interactions. Data are presented which demonstrate that metastasis suppressors act at multiple steps of the metastatic cascade. A brief discussion for how metastasis suppressor regulation of cellular interactions might be exploited is presented.

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