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. 2008 Dec;1(1):85-91.
doi: 10.1007/s12307-008-0008-1. Epub 2008 Mar 19.

Abnormal growth factor/cytokine network in gastric cancer

Eiichi Tahara  1
Affiliations

Abnormal growth factor/cytokine network in gastric cancer

Eiichi Tahara. Cancer Microenviron. 2008 Dec.

Abstract

Gastric cancer cells express a broad spectrum of the growth factor/cytokine receptor systems that organize the complex interaction between cancer cells and stromal cells in tumor microenvironment, which confers cell growth, apoptosis, morphogenesis, angiogenesis, progression and metastasis. However, these abnormal growth factor/cytokine networks differ in the two histological types of gastric cancer. Importantly, activation of nuclear factor-kB pathway by Helicobacter pylori infection may act as a key player for induction of growth factor/cytokine networks in gastritis and pathogenesis of gastric cancer. Better understanding of these events will no doubt provide new approaches for biomarkers of diagnosis and effective therapeutic targeting of gastric cancer.

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Figures

Fig. 1
Fig. 1
Tumor microenvironment of gastric cancer is composed of interaction between cancer cells and stromal cells via growth factor/cytokine network
See this image and copyright information in PMC

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