Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2009 Mar;54(4):486-9.
doi: 10.1111/j.1365-2559.2009.03245.x.

Bone marrow necrosis related to paracoccidioidomycosis: the first eight cases identified at autopsy

Lucilene S R Resende  1 , Rinaldo P Mendes, Maura M Bacchi, Sílvio A Marques, Benedito Barraviera, Lenice R Souza, Domingos A Meira, Lígia Niéro-Melo
Affiliations
Case Reports

Bone marrow necrosis related to paracoccidioidomycosis: the first eight cases identified at autopsy

Lucilene S R Resende et al. Histopathology. 2009 Mar.

Abstract

Aims: To report the first eight bone marrow necrosis (BMN) cases related to paracoccidioidomycosis (PCM) from patient autopsies with well-documented bone marrow (BM) histology and cytology.

Methods and results: A retrospective evaluation was performed on BM specimens from eight autopsied patients from Botucatu University Hospital with PCM-related BMN. Relevant BMN literature was searched and analysed.

Conclusions: All eight patients had acute PCM. Six had histological only (biopsies) and two cytological only (smears) specimens. Five biopsy specimens revealed severe and one mild coagulation patterned necrotic areas. Five had osteonecrosis. The cytological specimens also showed typical BMN patterns. Paracoccidioides brasiliensis yeast forms were visible within necrotic areas in all cases.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A, Case 1: Severe coagulative bone marrow necrosis (BMN) in an AIDS patient. Fungal cells can be observed within the ghosts of the dead hematopoietic cells (arrows). Bone marrow biopsy (BMB); H&E. B, Case 2: Extensive coagulative BMN. Bone trabecula was also affected (arrow). BMB; H&E. C, Case 5: Disarrangement of bone marrow architecture due to both parenchymal and trabecular severe BMN. BMB; H&E. D, Case 6: Necrotic bone trabecula in an extensive area of granulomatous reaction presenting numerous Paracoccidioides brasiliensis. Remnant of non-necrotic bone can be seen on its upper border (arrows). BMB; H&E. E, Case 7: Necrotic hematopoietic cells with a smudgy appearance. A stained smooth homogeneus background precipitate is present. Fungal cells can be seen (arrows). Aspirated smear; Giemsa. F, Case 8: Typical coagulative necrosis on aspirated smear. An agglomerate of histiocyte attempts to form a giant cell (arrow). Several P. brasiliensis are also present. Aspirated smear; Shorr.
See this image and copyright information in PMC

References

    1. Janssens AM, Offner FC, Van Hove WZ. Bone marrow necrosis. Cancer. 1988;88:1769–1780. - PubMed
    1. Wade L, Stevenson L. Necrosis of bone marrow with fat embolism in sickle cell anemia. Am. J. Pathol. 1941;17:47–54. Cited by Paydas S, Ergin M, Baslamisli F et al. Bone marrow necrosis: clinicopathologic analysis of 20 cases and review of the literature. Am. J. Hematol. 2002; 70; 300–305. - PMC - PubMed
    1. Conrad ME, Carpenter JT. Bone marrow necrosis. Am. J. Hematol. 1979;7:181–189. - PubMed
    1. Conrad ME. Bone marrow necrosis. J. Intensive Care Med. 1995;10:171–178. - PubMed
    1. Brown CH. Bone marrow necrosis: a study of seventy cases. Johns Hopkins Med. J. 1972;131:189–203. - PubMed

Publication types

MeSH terms