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. 2009 Apr 16;11(8):1721-4.
doi: 10.1021/ol9003349.

Enantioselective conjugate addition of nitroalkanes to vinyl sulfone: an organocatalytic access to chiral amines

Qiang Zhu  1 , Yixin Lu
Affiliations

Enantioselective conjugate addition of nitroalkanes to vinyl sulfone: an organocatalytic access to chiral amines

Qiang Zhu et al. Org Lett. .

Abstract

Organocatalytic asymmetric conjugate addition of nitroalkanes to vinyl sulfone mediated by cinchona alkaloid-derived thiourea catalyst afforded the desired Michael product with good enantioselectivity. The described method, in combination with ready desulfonation, represents a novel approach to access alpha-alkylated chiral amines.

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