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. 2009 Apr;73(4):376-8.
doi: 10.1111/j.1399-0039.2009.01227.x.

Assessment of the amino acid substitution in HLA-B*5719 for allorecognition

Affiliations

Assessment of the amino acid substitution in HLA-B*5719 for allorecognition

C Figueiredo et al. Tissue Antigens. 2009 Apr.

Abstract

The novel allele human leukocyte antigen (HLA)-B*5719 differs from HLA-B*5701 by a synonymous nucleotide exchange at position 539 in exon 3 (C-->T), replacing Leucine by Arginine at amino acid position 156 in the alpha2 domain.

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Figures

Figure 1
Figure 1
(A) Nucleotide sequence aligment of codons 150 - 174 of the HLA-B*57 group. (B) Amino acid sequence alignment of postions 150 - 174 of the HLA-B*57 group.
Figure 1
Figure 1
(A) Nucleotide sequence aligment of codons 150 - 174 of the HLA-B*57 group. (B) Amino acid sequence alignment of postions 150 - 174 of the HLA-B*57 group.

References

    1. Eiz-Vesper B, Deluca DS, Blasczyk R, Horn PA. The nature of recombination in HLA-B*4207. Tissue Antigens. 2007;70:164–8. - PubMed
    1. Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Geraghty DE, Hansen JA, Hurley CK, Mach B, Mayr WR, Parham P, Petersdorf EW, Sasazuki T, Schreuder GM, Strominger JL, Svejgaard A, Terasaki PI, Trowsdale J. Nomenclature for factors of the HLA system, 2004. Tissue Antigens. 2005;65:301–69. - PubMed
    1. Fleischhauer K, Avila D, Vilbois F, Traversari C, Bordignon C, Wallny HJ. Characterization of natural peptide ligands for HLA-B*4402 and -B*4403: implications for peptide involvement in allorecognition of a single amino acid change in the HLA-B44 heavy chain. Tissue Antigens. 1994;44:311–7. - PubMed
    1. Macdonald WA, Purcell AW, Mifsud NA, Ely LK, Williams DS, Chang L, Gorman JJ, Clements CS, Kjer-Nielsen L, Koelle DM, Burrows SR, Tait BD, Holdsworth R, Brooks AG, Lovrecz GO, Lu L, Rossjohn J, McCluskey J. A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition. J Exp Med. 2003;198:679–91. - PMC - PubMed
    1. Risler JL, Delorme MO, Delacroix H, Henaut A. Amino acid substitutions in structurally related proteins. A pattern recognition approach. Determination of a new and efficient scoring matrix. J Mol Biol. 1988;204:1019–29. - PubMed

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