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Review
. 2009 Apr 1;69(7):2699-703.
doi: 10.1158/0008-5472.CAN-08-4359. Epub 2009 Mar 24.

Potential stages for prostate cancer prevention with selenium: implications for cancer survivors

Nicole Facompre  1 , Karam El-Bayoumy
Affiliations
Review

Potential stages for prostate cancer prevention with selenium: implications for cancer survivors

Nicole Facompre et al. Cancer Res. .

Abstract

The lack of treatment for "worried well" patients with high-grade prostatic intraepithelial neoplasia combined with issues of recurrence and hormone resistance in prostate cancer survivors remains a major public health obstacle. The long latency of prostate cancer development provides an ample opportunity to intervene with mechanistically based chemopreventive agents at various stages of disease progression. Our rationale for selenium intervention is based on current mechanistic knowledge derived solely from preclinical investigations. Clearly, there is sufficient scientific support for its entry into current clinical trials, the outcome of which will be highly valuable in assessing whether selenium can be recommended for cancer survivors.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
A. Prostate cancer progression, treatment options, and opportunities for intervention with selenium. B. Cellular and molecular targets of selenium (Se) in vitro and in vivo related to prostate cancer progression.
See this image and copyright information in PMC

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