doi: 10.1126/science.193186.
Drug tolerance in biomembranes: a spin label study of the effects of ethanol
- PMID: 193186
- DOI: 10.1126/science.193186
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Drug tolerance in biomembranes: a spin label study of the effects of ethanol
Science.
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Abstract
Ethanol in vitro increased the fluidity of spin-labeled membranes from normal mice. Membranes from mice that had been subjected to long-term ethanol treatment were relatively resistant to this fluidizing effect. The data suggest that the membranes themselves had adapted to the drug, a novel form of drug tolerance.
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