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. 1977 May 6;196(4290):684-5.
doi: 10.1126/science.193186.

Drug tolerance in biomembranes: a spin label study of the effects of ethanol

J H Chin, D B Goldstein

Drug tolerance in biomembranes: a spin label study of the effects of ethanol

J H Chin et al. Science. .

Abstract

Ethanol in vitro increased the fluidity of spin-labeled membranes from normal mice. Membranes from mice that had been subjected to long-term ethanol treatment were relatively resistant to this fluidizing effect. The data suggest that the membranes themselves had adapted to the drug, a novel form of drug tolerance.

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