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Review
. 2009 Mar;23(3):210-4.
doi: 10.1155/2009/417296.

Colon cleansing before colonoscopy: does oral sodium phosphate solution still make sense?

D K Rex  1 , S J Vanner
Affiliations
Review

Colon cleansing before colonoscopy: does oral sodium phosphate solution still make sense?

D K Rex et al. Can J Gastroenterol. 2009 Mar.

Abstract
in English, French

Oral sodium phosphate (NaP) solution has been withdrawn from the market in the United States but remains available for over-the-counter purchase for bowel preparation for colonoscopy in Canada. The present review summarizes recent data regarding the renal toxicity of oral NaP as well as its efficacy and tolerability relative to other preparations. Given the availability of effective alternatives to NaP solution, its use for colonoscopy preparation in Canada should be limited. Candidate patients for oral NaP solution should be assessed for eligibility and preparation instructions should adhere to the current recommendations for maximizing the safety of oral NaP.

La solution de phosphate de sodium (NaP) par voie orale est retirée du marché aux États-Unis mais offerte en vente libre au Canada pour les préparations intestinales de coloscopie. La présente analyse résume les données récentes au sujet de la toxicité rénale de la NaP par voie orale ainsi que de son efficacité et de sa tolérabilité par rapport à d’autres préparations. Puisqu’il existe des préparations efficaces pour remplacer la solution de NaP, il faudrait en limiter l’usage pour les préparations de coloscopie au Canada. Il faudrait évaluer les patients candidats à une solution de NaP par voie orale afin de déterminer leur admissibilité et de s’assurer que les directives de préparation respectent les recommandations actuelles afin de porter l’innocuité du NaP par voie orale au maximum.

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References

    1. Harewood GC, Wiersema MJ, Melton LJ., III A prospective, controlled assessment of factors influencing acceptance of screening colonoscopy. Am J Gastroenterol. 2002;97:3186–94. - PubMed
    1. Vanner SJ, MacDonald PH, Paterson WG, Prentice RS, Da Costa LR, Beck IT. A randomized prospective trial comparing oral sodium phosphate with standard polyethylene glycol-based lavage solution (Golytely) in the preparation of patients for colonoscopy. Am J Gastroenterol. 1990;85:422–7. - PubMed
    1. Barkun A, Chiba N, Enns R, et al. Commonly used preparations for colonoscopy: Efficacy, tolerability, and safety – a Canadian Association of Gastroenterology position paper. Can J Gastroenterol. 2006;20:699–710. - PMC - PubMed
    1. Hookey LC, Depew WT, Vanner S. The safety profile of oral sodium phosphate for colonic cleansing before colonoscopy in adults. Gastrointest Endosc. 2002;56:895–902. - PubMed
    1. Markowitz GS, Stokes MB, Radhakrishnan J, D’Agati VD. Acute phosphate nephropathy following oral sodium phosphate bowel purgative: An under-recognized cause of chronic renal failure. J Am Soc Nephrol. 2005;16:3389–96. - PubMed