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. 1991 Nov 5;30(44):10813-7.
doi: 10.1021/bi00108a030.

Identification of an inhibitor of microtubule assembly present in juvenile brain which displays a novel mechanism of action involving suppression of self-nucleation

C D Surridge  1 , R G Burns
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Identification of an inhibitor of microtubule assembly present in juvenile brain which displays a novel mechanism of action involving suppression of self-nucleation

C D Surridge et al. Biochemistry. .

Abstract

An inhibitor of microtubule assembly has been identified and partially purified from microtubule-depleted brain extracts from day-old chicks and 4-month-old calf. This inhibitor suppresses the self-nucleation of microtubules in vitro with minimal effect upon the final extent of assembly. It may have a developmental role in vivo as it is not detected in adult brain from either cattle or rabbit.

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