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. 2009 Apr 2;11(7):1627-30.
doi: 10.1021/ol9003433.

Catalytic asymmetric oxa-Michael-Michael cascade for facile construction of chiral chromans via an aminal intermediate

Liansuo Zu  1 , Shilei Zhang, Hexin Xie, Wei Wang
Affiliations

Catalytic asymmetric oxa-Michael-Michael cascade for facile construction of chiral chromans via an aminal intermediate

Liansuo Zu et al. Org Lett. .

Abstract

An unprecedented highly enantioselective cascade oxa-Michael-Michael reaction has been developed. The simple and practical process, efficiently catalyzed by chiral diphenylprolinol TMS ether, affords a powerful access to highly functionalized synthetically useful chiral chromans. Moreover, notably a new activation mode involving an aminal is disclosed for the first time.

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