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Editorial
. 2009 Jan-Mar;23(1):11-4.

The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator

M L Castellani, D Kempuraj, V Salini, J Vecchiet, S Tete, C Ciampoli, F Conti, G Cerulli, A Caraffa, P Antinolfi, T C Theoharides, D De Amicis, A Perrella, C Cuccurullo, P Boscolo, Y Shaik
  • PMID: 19321041
Editorial

The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator

M L Castellani et al. J Biol Regul Homeost Agents. 2009 Jan-Mar.

Abstract

IL-33, a member of IL-1 family, induces the differentiation of T-cells (depending on the phosphorylation of MAPKs and NF-kB) and is involved in T-cell mediated immune responses. IL-33 is also involved in the production of IL-5, IL-4 and IL-13 and several chemokines. In this editorial we show the importance of IL-33 in allergic diseases and its role as an inflammatory cytokine. In addition, the induction of certain chemokines by IL-33 may candidate this new cytokine as a mediator in inflammatory and autoimmune diseases and may prove to be a therapeutic target for the prevention of these diseases.

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