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. 1991 Oct 8;1090(2):241-4.
doi: 10.1016/0167-4781(91)90109-y.

Hem-1, a potential membrane protein, with expression restricted to blood cells

R Hromas  1 , S Collins, W Raskind, L Deaven, K Kaushansky
Affiliations

Hem-1, a potential membrane protein, with expression restricted to blood cells

R Hromas et al. Biochim Biophys Acta. .

Abstract

Overlapping cDNAs 3.8 kb in length containing a long open reading frame were obtained that hybridized exclusively to transcripts from hematopoietic cells. Sequence analysis found eight potential membrane domains and two possible cAMP/cGMP phosphorylation sites. This sequence exhibited no homologies with the EMBL/Genbank nucleic acid, SwissProt or GenPept amino acid data bases. The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A.

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