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. 2009 May;47(5):1463-8.
doi: 10.1128/JCM.02467-08. Epub 2009 Mar 25.

Less-frequent Fusarium species of clinical interest: correlation between morphological and molecular identification and antifungal susceptibility

Mónica Azor  1 , Josepa Gené, Josep Cano, Palanisamy Manikandan, Narendran Venkatapathy, Josep Guarro
Affiliations

Less-frequent Fusarium species of clinical interest: correlation between morphological and molecular identification and antifungal susceptibility

Mónica Azor et al. J Clin Microbiol. 2009 May.

Abstract

Forty-eight Fusarium isolates morphologically identified as belonging to seven species of clinical interest (i.e., Fusarium chlamydosporum, Fusarium dimerum, Fusarium incarnatum, Fusarium napiforme, Fusarium nygamai, Fusarium proliferatum, and Fusarium sacchari) were characterized molecularly by the analysis of the sequences of the TUB region of the beta-tubulin gene. F. chlamydosporum and F. dimerum were the most genetically heterogeneous species. A high degree of correlation between the morphological and molecular identification was shown among the isolates studied. A table with the key morphological features for the identification of these Fusarium species is provided. The antifungal susceptibilities of the Fusarium isolates to 11 antifungal drugs were tested; terbinafine was the most active drug against all the species tested with the exception of F. incarnatum, for which amphotericin B was the most active.

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Figures

FIG. 1.
FIG. 1.
One of the 225 most parsimonious trees obtained from heuristic searches based on TUB sequences. Bootstrap support values are indicated at the nodes. CI, consistency index; HI, homoplasy index; RI, retention index; asterisks, accession numbers of sequences retrieved from GenBank.
See this image and copyright information in PMC

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