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. 2009 Mar 26;360(13):1355-7.
doi: 10.1056/NEJMcibr0810752.

A lesson in tolerance--maternal instruction to fetal cells

William J Burlingham  1
Affiliations

A lesson in tolerance--maternal instruction to fetal cells

William J Burlingham. N Engl J Med. .
No abstract available

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1. Immunity and the Maternal–Fetal Axis
Mold and colleagues recently described a mechanism through which fetal tolerance of maternal antigens is initiated. Noninherited HLA antigens (orange) and inherited maternal HLA antigens (blue) are shown. Noninherited maternal HLA antigens include intact HLA recognized by fetal effector T cells and maternal peptides recognized by the FOXP3-positive regulatory T cells. The different results of effector T cells versus regulatory T-cell pathways with respect to the persistence of mature maternal cells (microchimerism) are indicated.
See this image and copyright information in PMC

References

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