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Randomized Controlled Trial
. 2009 Apr;30(2):131-9.
doi: 10.1097/DBP.0b013e31819e6a48.

The effects of iron and/or zinc supplementation on maternal reports of sleep in infants from Nepal and Zanzibar

Katarzyna Kordas  1 , Emily H Siegel, Deanna K Olney, Joanne Katz, James M Tielsch, Patricia K Kariger, Sabra S Khalfan, Steven C LeClerq, Subarna K Khatry, Rebecca J Stoltzfus
Affiliations
Randomized Controlled Trial

The effects of iron and/or zinc supplementation on maternal reports of sleep in infants from Nepal and Zanzibar

Katarzyna Kordas et al. J Dev Behav Pediatr. 2009 Apr.

Abstract

Background: There is some evidence that sleep patterns may be affected by iron deficiency anemia but the role of iron in sleep has not been tested in a randomized iron supplementation trial.

Objective: We investigated the effect of iron supplementation on maternal reports of sleep in infants in 2 randomized, placebo-controlled trials from Pemba Island, Zanzibar, and Nepal.

Design: In both studies, which had parallel designs and were carried out in years 2002 to 2003, infants received iron-folic acid with or without zinc daily for 12 months, and assessments of development were made every 3 months for the duration of the study. Eight hundred seventy-seven Pemban (12.5 +/- 4.0 months old) and 567 Nepali (10.8 +/- 4.0 months) infants participated. Maternal reports of sleep patterns (napping frequency and duration, nighttime sleep duration, frequency of night waking) were collected.

Results: Mean Hb concentration was 9.2 +/- 1.1 for Pemban and 10.1 +/- 1.2 g/dL for Nepali infants. Approximately, one-third of the children were stunted. Supplemental iron was consistently associated with longer night and total sleep duration. The effects of zinc supplementation also included longer sleep duration.

Conclusions: Micronutrient supplementation in infants at high risk for iron deficiency and iron deficiency anemia was related to increased night sleep duration and less night waking.

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References

    1. Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr. 2001;131(2S2):649S–666S. discussion 666S–668S. - PubMed
    1. McCann JC, Ames BN. An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am J Clin Nutr. 2007;85:931–945. - PubMed
    1. Olney DK, Pollitt E, Kariger PK, et al. Combined iron and folic acid supplementation with or without zinc reduces time to walking unassisted among Zanzibari infants 5- to 11-mo old. J Nutr. 2006;136:2427–2434. - PubMed
    1. Black MM, Baqui AH, Zaman K, et al. Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants. Am J Clin Nutr. 2004;80:903–910. - PubMed
    1. Lozoff B, De Andraca I, Castillo M, Smith JB, Walter T, Pino P. Behavioral and developmental effects of preventing iron-deficiency anemia in healthy full-term infants. Pediatrics. 2003;112:846–854. - PubMed

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