Review
doi: 10.1002/ibd.20910.
Indoleamine 2,3-dioxygenase in intestinal immunity and inflammation
Affiliations
- PMID: 19322906
- DOI: 10.1002/ibd.20910
Item in Clipboard
Review
Indoleamine 2,3-dioxygenase in intestinal immunity and inflammation
Inflamm Bowel Dis.
2009 Sep.
Abstract
Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catabolizing enzyme that has a number of immunoregulatory effects. It is expressed at high levels in the gastrointestinal tract, particularly in the small intestine, and has been implicated in the control of intestinal inflammation. However, its precise role in intestinal immunity is not well understood. This review will summarize the current state of knowledge about IDO function, particularly as it pertains to inflammatory responses in the gut.
Similar articles
-
Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction.Gut. 2010 May;59(5):595-604. doi: 10.1136/gut.2009.185108. Gut. 2010. PMID: 20427394
-
Western diet-induced anxiolytic effects in mice are associated with alterations in tryptophan metabolism.Nutr Neurosci. 2016 Oct;19(8):337-345. doi: 10.1179/1476830515Y.0000000034. Epub 2015 Jun 18. Nutr Neurosci. 2016. PMID: 26086200
-
Regulatory lymphocytes and intestinal inflammation.Annu Rev Immunol. 2009;27:313-38. doi: 10.1146/annurev.immunol.021908.132657. Annu Rev Immunol. 2009. PMID: 19302043 Review.
-
Indoleamine 2,3 dioxygenase and regulation of T cell immunity.Biochem Biophys Res Commun. 2005 Dec 9;338(1):20-4. doi: 10.1016/j.bbrc.2005.08.232. Epub 2005 Sep 8. Biochem Biophys Res Commun. 2005. PMID: 16157293 Review.
-
Indoleamine 2,3-dioxygenase expression is associated with chronic rhinosinusitis: review of the evidence.Curr Opin Allergy Clin Immunol. 2013 Feb;13(1):37-44. doi: 10.1097/ACI.0b013e32835b350e. Curr Opin Allergy Clin Immunol. 2013. PMID: 23128419 Review.
Cited by
-
Indoleamine 2,3 dioxygenase in intestinal disease.Curr Opin Gastroenterol. 2013 Mar;29(2):146-52. doi: 10.1097/MOG.0b013e32835c9cb3. Curr Opin Gastroenterol. 2013. PMID: 23283180 Free PMC article. Review.
-
Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver.Genome Biol. 2014 Jun 19;15(6):R79. doi: 10.1186/gb-2014-15-6-r79. Genome Biol. 2014. PMID: 24946870 Free PMC article.
-
A role of the aryl hydrocarbon receptor in attenuation of colitis.Dig Dis Sci. 2011 Sep;56(9):2532-44. doi: 10.1007/s10620-011-1643-9. Epub 2011 Mar 5. Dig Dis Sci. 2011. PMID: 21374063
-
Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-γ.PLoS Pathog. 2011 Apr;7(4):e1002016. doi: 10.1371/journal.ppat.1002016. Epub 2011 Apr 14. PLoS Pathog. 2011. PMID: 21533215 Free PMC article.
-
Increased density of tolerogenic dendritic cells in the small bowel mucosa of celiac patients.World J Gastroenterol. 2015 Jan 14;21(2):439-52. doi: 10.3748/wjg.v21.i2.439. World J Gastroenterol. 2015. PMID: 25593459 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials