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Comparative Study
. 2009 May 15;172(2):136-9.
doi: 10.1016/j.pscychresns.2009.02.005. Epub 2009 Mar 25.

Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder

Paul Daniel Arnold  1 , Frank P Macmaster, Margaret A Richter, Gregory L Hanna, Tricia Sicard, Eliza Burroughs, Yousha Mirza, Phillip C Easter, Michelle Rose, James L Kennedy, David R Rosenberg
Affiliations
Comparative Study

Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder

Paul Daniel Arnold et al. Psychiatry Res. .

Abstract

In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.

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Figures

Figure 1
Figure 1
1H-MRS voxel placement (A) and Sample Spectra from the Anterior Cingulate and Occipital Lobe
See this image and copyright information in PMC

References

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