Antioxidant therapy: reducing malaria severity?

Editorial

Hans C Ackerman et al. Crit Care Med. 2009 Feb.

. 2009 Feb;37(2):758-60.

doi: 10.1097/CCM.0b013e318194d5de.

No abstract available

Conflict of interest statement

The authors have not disclosed any potential conflicts of interest.

N-acetylcysteine as adjunctive treatment in severe malaria: a randomized, double-blinded placebo-controlled clinical trial.
Charunwatthana P, Abul Faiz M, Ruangveerayut R, Maude RJ, Rahman MR, Roberts LJ 2nd, Moore K, Bin Yunus E, Hoque MG, Hasan MU, Lee SJ, Pukrittayakamee S, Newton PN, White NJ, Day NP, Dondorp AM. Charunwatthana P, et al. Crit Care Med. 2009 Feb;37(2):516-22. doi: 10.1097/CCM.0b013e3181958dfd. Crit Care Med. 2009. PMID: 19114891 Free PMC article. Clinical Trial.

1. Snow RW, Guerra CA, Noor AM, et al. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature. 2005;434:214–217. - PMC - PubMed
1. Dondorp A, Nosten F, Stepniewska K, et al. Artesunate versus quinine for treatment of severe falciparum malaria: A randomised trial. Lancet. 2005;366:717–725. - PubMed
1. Planche T, Onanga M, Schwenk A, et al. Assessment of volume depletion in children with malaria. PLoS Med. 2004;1:e18. - PMC - PubMed
1. Ockenhouse CF, Ho M, Tandon NN, et al. Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: Differential adhesion of infected erythrocytes to CD36 and ICAM-1. J Infect Dis. 1991;164:163–169. - PubMed
1. Francischetti IM, Seydel KB, Monteiro RQ. Blood coagulation, inflammation, and malaria. Microcirculation. 2008;15:81–107. - PMC - PubMed